Colloidal, polymeric and biologically active interfaces for design of biomimetic materials and semi-synthetic cells
The Subramaniam Lab seeks to understand the fundamental physicochemical mechanisms that govern the assembly and function of biomembranes. Students learn to use experimental approaches in soft matter physics, chemistry, and molecular biology to tackle cutting-edge challenges in biomembrane engineering and bottom-up synthetic biology. Current topics of interest include developing methods of high throughput fabrication of semi-synthetic cells and developing cost effective vesicle-based therapeutics and diagnostics to improve public health.
- A.B. Subramaniam, G. Guidotti, V.N. Manoharan and H.A. Stone. Glycans pattern the phase behavior of lipid membranes. Nature Materials, 12, 128 (2013) https://www.nature.com/articles/nmat3492. News and Views by Jay T. Groves, Nature Materials, 12, 96-97 (2013).
- K.M. Kresse*, M. Xu*, J. Pazzi, M. Garcia-Ojeda, A.B. Subramaniam. Novel application of cellulose paper as a platform for the macromolecular self-assembly of biomimetic giant liposomes. ACS Applied Materials & Interfaces 8 (47), 32102–32107 (2016). *Equal Contribution https://pubs.acs.org/doi/abs/10.1021/acsami.6b11960
- A. Li*, J. Pazzi*, M. Xu, A.B. Subramaniam. Cellulose abetted assembly and temporally-decoupled loading of cargo into vesicles synthesized from functionally diverse lamellar phase forming amphiphiles. Biomacromolecules 19, 849-859 (2018). *Equal Contribution https://pubs.acs.org/doi/10.1021/acs.biomac.7b01645