Bioengineering seminars will take place on Fridays during the Fall 2019 semester. The seminar will be held from 10:30 to 11:45 a.m. in COB 110.
"Tuning Protein Structure by Changing Solution Conditions"
Shahar Sukenik, Dept. of Chemistry and Chemical Biology, UC Merced
For decades, protein function has been understood in the context of their three-dimensional structure. More recently, a new class of intrinsically disordered proteins (IDPs) has upended this convention. Unlike well-folded proteins, IDP activity is determined by structural preferences in an ensemble of rapidly interchanging conformations that can strongly depend on solution conditions. We use a multi-scale approach to measure IDP structural changes in silico, in the test tube, and in live cells. Our experiments reveal that IDPs can possess a highly tunable structural ensemble that depends on the chemical composition of their environment as much as it does on protein sequence.
Joel Spencer, Bioengineering, UC Merced
Chih-Wen Ni, Bioengineering, UC Merced
Michael Hagan, Computational Biology & Bioengineering, Brandeis University, Department of Physics
Eva de Alba, Bioengineering, UC Merced
Liposome-binding proteins for drug delivery; Protein dynamics from NMR relaxation and implications in self-assembly
Arvind Gopinath, Bioengineering, UC Merced
For information, please contact contact Professor Victor Muñoz.