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Seminars

Bioengineering seminars will take place on Fridays during the Fall 2019 semester. The seminar will be held from 10:30 to 11:45 a.m. in COB 110.

Oct. 25

"Tuning Protein Structure by Changing Solution Conditions"

Shahar Sukenik, Dept. of Chemistry and Chemical Biology, UC Merced

Abstract

For decades, protein function has been understood in the context of their three-dimensional structure. More recently, a new class of intrinsically disordered proteins (IDPs) has upended this convention. Unlike well-folded proteins, IDP activity is determined by structural preferences in an ensemble of rapidly interchanging conformations that can strongly depend on solution conditions. We use a multi-scale approach to measure IDP structural changes in silico, in the test tube, and in live cells. Our experiments reveal that IDPs can possess a highly tunable structural ensemble that depends on the chemical composition of their environment as much as it does on protein sequence.

Nov. 1

Joel Spencer, Bioengineering, UC Merced

Nov. 8

Chih-Wen Ni, Bioengineering, UC Merced

Nov. 15

Michael Hagan, Computational Biology & Bioengineering, Brandeis University, Department of Physics

Nov. 22

Eva de Alba, Bioengineering, UC Merced

Liposome-binding proteins for drug delivery; Protein dynamics from NMR relaxation and implications in self-assembly

Nov. 29

Thanksgiving

Dec. 6

Arvind Gopinath, Bioengineering, UC Merced

 

For information, please contact contact Professor Victor Muñoz.